To improve the damage efficiency of warhead, the fluorine polymer based energetic reactive materials were studied. The formulation of the fluorine polymer based energetic material was improved and a kind of energetic kill element with dimension of Φ26 mm×60 mm was prepared. Experimental study on shock Initiation of simulative warhead was carried out, in which the energetic kill element was confined by a shell with specific structure. The explosion situation after the energetic kill element penetrated into the warhead was observed by high-speed video and the air shock wave overpressure after explosion was measured. The ignition and blasting ability of the energetic kill element to detonate Comp.B and PBX-9404 under different speeds was examined. The static detonation test of Comp.B simulation warhead for comparison was set. Based on the test, through the measurement of air shock wave overpressure after explosion, the comparison and analysis of the equivalent TNT equivalent was performed. Experimental study show that under the penetration speed of 735 m·s^-1, the energetic kill element can detonate the Comp.B warhead. Under the penetration speed of 962 m·s^-1, the energetic kill element can arouse the Comp.B warhead deflagration.