To study the fuel dispersion and detonation process at a falling speed of 1000 m·s^-1， a computational simulation model of fuel dispersion detonation was established， and the static fuel dispersion and cloud detonation experimental results were used as numerical methods to verify the results. Results show that under the condition of a falling speed of 1000 m·s^-1， the distribution of cloud shape and concentration field with time and space is obtained by numerical simulation. The cloud shape is roughly fan-shaped， and the concentration gradually decreases with distance， and finally reaches a stable distribution. The radial radius of the cloud can reach 2.24 m. The law of the cloud detonation process and the influence of the detonation pressure field and temperature field are obtained. After initiation， the arc-shaped wave front is formed and diffuses outward， and the temperature and pressure continue to decay. The numerical simulation results are consistent with the experiments， which provide a new way for the safety design of the high-falling velocity cloud explosion weapon system.