To explore the liquid components of high-potential Fuel air explosive（FAE） with better damage power， taking the traditional typical fuel （propylene oxide） as reference， polymethoxy dibutyl ethe（BTPOM_n）， polymethoxy dimethyl ether （DMM₂）， 1-butanol and 2-butyl alcohol were selected as research object. A pressure testing system， high-speed camera and infrared thermal image were used to record the experimental data. The cloud explosive characteristics of the 5 fuels with 18g RDX as central burster charge and 160g TNT as secondary explosive were studied. The results indicated that the critical initiation energy of the DMM₂was higher than that of the other fuels. The relationship of the damage radius of thermal radiation among 5 fuels was as follows： propylene oxide （18.9 m）＞2-butyl alcohol （16.6 m）＞1-butanol （16.0 m）＞DMM₂ （15.6 m）＞BTPOM_n （12 m）. The damage effects of 5 fuels on people and buildings were evaluated by the PROBIT equation， and the results showed that the damage effects of 1-butanol and 2-butyl alcohol were better than those of BTPOM_n and DMM₂， and the propylene oxide had the best damage effect.