In order to obtain spherical granulations with regular shape， good dispersibility and uniform particle size， the effects of different binders on 2，2"，4，4"，6，6"-hexanitrodiphenylethylene （HNS） composite microspheres were studied by using droplet microfluidic technology. Fluoroelastomer （F₂₆₀₄）， nitrocellulose （NC） and glycidyl azide polymer （GAP） were selected to prepare spherical granulation of submicron HNS， and submicron-level HNS/F₂₆₀₄ （95/5）， HNS/NC （95/5） and HNS/GAP （95/5） composite microspheres were successfully prepared. Resultant microspheres were characterized by scanning electron microscope， X-ray diffractometer， specific surface area， thermal analyzer， true density tester and mechanical sensitivity tester. Results indicated that such methods could obtain the HNS composite microspheres with high sphericity， monodisperse， narrow size distribution， good roundness and improved safety performances. The average circularities were 0.934， 0.915 and 0.925 with D₅₀ of 45.39， 58.68 μm and 45.43 μm （the span was less than 0.55）， respectively. Thermal decomposition peak temperatures were 354.44， 349.53 ℃ and 339.37 ℃ for HNS/F₂₆₀₄， HNS/NC and HNS/GAP， respectively. The spheroidization process increases the true density of the microspheres to 1.9408， 1.9383 g·cm^-3 and 1.9204 g·cm^-3， respectively， which can effectively improve the HNS charge performance. The cone angles of 27°， 24.3°， and 24° indicated that microspheres have good dispersion performances. Compared with submicron HNS， the impact sensitivity of the three microspheres was increased by 5.5， 4， 3.5 J， and the friction sensitivity was increased by 52， 36 N and 4 N， respectively， indicating a better safety performance.