The cast TiZrNbV refractory high entropy alloy （RHEA） has high structural strength and good energy release characteristics. As an energetic structural material， it needs to withstand complex dynamic load environments in engineering applications. Studying the spalling behavior of TiZrNbV refractory high entropy alloy and obtaining accurate dynamic constitutive parameters are vital for its engineering application. The spalling characteristics of TiZrNbV RHEA were studied by flat plate impact experiment using a 20mm light gas gun. Parameters such as spalling strength， Hugoniot elastic limit （HEL）， and plastic strain rate were obtained， based on the free surface velocity history. The recycled specimens were analyzed using scanning electron microscopy （SEM）， and the spalling characteristics of TiZrNbV RHEA at different strain rates were analyzed from both macro and micro perspectives. It was shown that the geometrically necessary dislocation of the samples significantly increased with the increase of loading velocity. The spalling strength of TiZrNbV RHEA increases with the loading strain rate and the loading stress， with values ranging from 0.93 GPa to 2.23GPa. The GTN-JC constitutive model parameters of TiZrNbV RHEA were obtained by calibrating the free surface velocity history of the spallation experiment with a flyer velocity of 580 m·s^-1. The spallation behavior of the sample under 610 m·s^-1 flyer velocity loading was calculated by using the fitted parameters. It was indicated that the free surface velocity curve of the spallation experiment performed well in simulating the spallation behavior of coarse-grained TiZrNbV RHEA. The simulation results show that the free surface velocity curve is consistent before the first tensile stage， which can be used for the dynamic analysis of sample spalling failure. The obtained parameters can provide reference for the engineering application of TiZrNbV RHEA.