The intermediate 1, 3-ditertiobutyl-5, 5-dinitrohexahydropyrimidine was prepared via Mannich reaction using 2, 2-dinitropropane-1, 3-diol, formaldehyde and tert-butylamine as materials, and 1, 3, 5, 5-tetranitrohexahydropyrimidine(DNNC) was obtained finally in total yield of 76% and purity of 99%. The DNNC was characterized by IR, NMR, MS spectra, elemental analyses and DSC. The results show that the decomposition temperature of DNNC is 222.2 ℃, and the friction and impact sensitivities of DNNC are 60% and 28.5 cm, respectively, showing a better thermal stability and lower mechanical sensitivity.