The desensitizing technology of ammonium perchlorate(AP) was studied by coated with wax or themoplastic polyurethane(TPU) as insensitive coating desensitizer. The feasibility study of AP coated by wax and TPU were proved through surface interaction. The coated samples were characterized by using SEM and XPS, and the mechanical sensitivity of AP samples before and after coating was measured and compared. The coupling relations between AP and explosive RDX were studied and the application of coated AP in typical cast PBX was investigated. Results show that AP may be entirely coated by wax and TPU, and the impact and friction sensitivity of AP coated by wax decrease significantly from 100% to 4%, from 100% to 24%, respectively. It indicates that AP is coated more entirely in non-aqueous media(Novec 7200)than in saturated water solution and the coated AP is insensitive which the impact and friction sensitivity fall to 0%. There are strong coupling relations between oxidizer AP and explosive RDX, but it can be reduced or diminished by the desensitizer. The safety of representative cast plastic bonded explosive can be significantly improved by using coated AP instead of uncoated AP, which friction sensitivity decreases significantly from 82% to 0, and the ignition temperature and time-to-explosive in slow cook-off increase 17 ℃ and 14 min, respectively.