In order to improve the reliability analysis of the explosive initiator with small sample size, a method based on generalized linear models of reliability analysis for explosive initiator was proposed according to sensitivity test and characteristics of reliability analysis.The likelihood function was transformed to a generalized linear expression of binomial variable.Using the generalized linear model for binomial distribution, the maximum likelihood estimations of the model coefficients were obtained, and corresponding arithmetic was put forward.With the asymptotic normality of maximum likelihood estimations, the approximated confidence interval for the reliability was obtained by logit transform of reliability fuaction.The present method was validated by the test data of stab detonator and electronic detonator.Results show that using about 150 samples is available to analysis the explosive initiator with a reliability goal of 0.999 by the method in this research.