Based on the fact that explosives are insensitive to microwave radiations under some conditions, microwave desiccation had been applied to all of the coarse-grained TATB, submicron TATB and fine RDX. The experimental results show that it is possible to substitute high temperature drying with microwave desiccation for coarse-grained TATB. In combination of low temperature drying and microwave desiccation, the specifications of the dried coarse-grained TATB could meet the requirements. For both of the submicron TATB and fine RDX, the microwave desiccation possesses advantages of high efficiency and high speed while without remarkable particle agglomeration.