Aiming at the reliability evaluation of the energy transmission interface of pyrotechnic sequence, a reliability evaluation method based on fiducial inference method was proposed. This method fully considers the randomness characteristics of the energy transfer interface data. By constructing the probability distribution model of the performance parameters, the prior knowledge is organically combined with the test data, and the accurate evaluation and randomness quantification of the interface reliability are realized. Firstly, the reliability model of the energy transfer interface of pyrotechnic sequence was established. On this basis, the reliability evaluation algorithm framework based on fiducial inference was designed. In order to verify the effectiveness of the proposed method, the evaluation results of the quantile correction method and the Monte Carlo method were compared and analyzed. The results show that when the sample size is 3 to 70, the deviation between the evaluation results based on the fiducial inference method and the true value is the smallest, and it has good convergence and stability. Especially when the sample size is less than or equal to 10, this method shows significant advantages, effectively overcomes the dependence of traditional methods on sample size, and provides a new method for the reliability evaluation of the energy transfer interface of pyrotechnic sequences.