2,4-Dinitroanisole (DNAN) is a promising alternative that possesses suitable melt point and adequate properties,may enable the development of a new class of low sensitivity melt-cast formulations for use in IM by virtue of reduced sensitivity. Synthesis and properties of DNAN including thermal characteristic and compatibility with relevant materials were overviewed. As a key ingredient in low sensitivity melt-castable explosives,DNAN-based formulations were also reviewed.