A novel cage-like compound tricyclo［3.3.1.0³^，⁷］nonane-2，6-dione was synthesized from bicyclic［3.3.1］non-2，6-dione through bromination， cyclization and reductive debromination. Its energetic derivative 2，2，6，6-tetranitrotricyclo［3.3.1.0³^，⁷］nonane was prepared via oximation and gem-dinitration. The structure of target compound was characterized by Fourier transform infrared spectroscopy （FT-IR）， nuclear magnetic resonance （NMR）， elemental analysis （EA）， and single crystal X-ray diffraction （SC-XRD）. The thermal stability was studied by differential scanning calorimetry （DSC） and thermogravimetric analysis （TG）. The detonation performances were predicted by EXPLO5. Results show that 2，2，6，6-tetranitrotrycyclo［3.3.1.0³^，⁷］nonane crystallizes in the monoclinic crystal system， space group P2/n with a crystal density of 1.691 g∙cm^-3. Its onset thermal decomposition temperature is 186 ℃. The theoretical detonation velocity and detonation pressure are 7319 m·s^-1 and 21.57 GPa， respectively， which are much higher than that of its adamantane-based homologue 2，2，6，6-tetranitroadamantane.