Tubular channel reactors possess superior advantages of efficient mass and heat transfer， which lays a solid foundation for the industrial transformation of mixing-controlled strongly exothermic reactions from traditional batch processes to continuous-flow processes. In this work， the synthesis of 3-amino-4-aminoximinofurazan （AAOF） was taken as the research subject. First， reaction calorimetry experiments were carried out to acquire the fundamental heat release data during the reaction process. Combined with material balance and heat balance calculations， the characteristic parameters of the exothermic model inside the tubular channel reactor were determined， and a coupled heat transfer-exothermic model was subsequently established. A numerical solution method was employed to simulate the jacket heat transfer capacity， heat transfer rate， and heat exchange efficiency of the heat transfer medium. On the basis of the simulation results， the thermal safety risks existing in the continuous-flow reaction process were analyzed， and a targeted heat exchange control scheme was proposed accordingly.The results reveal that under the fixed structural parameters of the tubular channel reactor （inner diameter of 0.01 m， tube length of 5 m） and AAOF production capacity of 2 kg·h^-1， when heat conduction oil is used as the heat exchange medium in the cocurrent flow mode， its mass flow rate exerts a remarkable influence on process thermal safety. When the mass flow rate is lower than 0.1 kg·h^-1， the outlet temperature of the tubular reactor exceeds 120 ℃， approaching the initial decomposition temperature of AAOF reaction solution （121.7 ℃）， which is liable to induce heat accumulation and further reaction runaway. The optimal heat removal performance is achieved at a mass flow rate range of 2-3.5 kg·h^-1. When the mass flow rate exceeds 4.5 kg·h^-1， the system temperature drops below 100 ℃ and cannot satisfy the required process temperature conditions. The optimal mass flow rate range of the heat transfer medium is finally determined to be 2-3.5 kg·h^-1. This study provides basic fundamental data and parametric guidance for the process safety design and stable long-term operation of AAOF preparation in tubular channel reactors.